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Fusion Gene Contributes To Progression Of Glioblastoma

Fusion genes are common chromosomal aberrations in many cancers, and can be used as prognostic markers and drug targets in clinical practice.

In this issue of the , researchers led by Matti Annala at in Finland identified a fusion between the FGFR3 and TACC3 genes in human samples. The protein produced by this promoted tumor growth and progression in a mouse model of , while increased expression of either of the normal genes did not alter tumor progression.

Ivan Babic and of the University of California, San Diego, explain in the accompanying commentary that it remains unclear how this mediates tumorigenesis. TITLE: The tumorigenic fusion FGFR3-TACC3 escapes miR-99a regulation in glioblastoma


ACCOMPANYING COMMENTARY TITLE: Multiple functions of a glioblastoma fusion oncogene



Journal of Clinical Investigation