Retrospective chart review also showed GeneSight results can help predict increased healthcare visits and higher disability claim benefits
The combinatorial, multi-gene GeneSight test has been found to better predict antidepressant treatment outcomes for patients with depression, and their use of health care resources, than any of the individual genes that comprise the test, according to a peer-reviewed analysis by investigators from the Mayo Clinic and Assurex Health, and published online by The Pharmacogenomics Journal.
The proprietary technology of the GeneSight Psychotropic test is based on combinatorial pharmacogenomics (CPGx™), the study of how variations in multiple genes collaborate to influence an individual’s response to medications, and evidence-based medicine and the known clinical pharmacology of various drugs.
“This new publication shows that the combinatorial GeneSight test predicts which patients are likely to experience poorer antidepressant outcomes and use more health care services, whereas single gene diagnostics mostly did not,” said lead author and Assurex Health Senior Vice President, C. Anthony Altar, Ph.D. “The robust evidence from these analyses reinforce the advantage of the combinatorial GeneSight test in helping clinicians guide antidepressant and anti-anxiety treatment decisions. This and other features of GeneSight distinguish our pharmacogenomic products from all others.”
The GeneSight Psychotropic test helps inform clinicians’ treatment selection for commonly prescribed medications including those for depression, post-traumatic stress disorder (PTSD), anxiety, bipolar disorder and schizophrenia. The test is covered by Medicare, the U.S. Department of Veterans Affairs, and a growing number of commercial payers.
Evaluating Drug Metabolism with Genetic Data
The CPGx approach that generates the GeneSight report examines DNA variations of multiple genes since these variations can change the efficacy, metabolism, and adverse effects of many psychiatric drugs. Using a patient’s unique genetics, the GeneSight Psychotropic test creates a personalized report that places 38 U.S. Food and Drug Administration (FDA)-approved medications for depression and other mental health conditions into three color-coded categories for clinicians to review: “Use as Directed” in green, “Use with Caution” in yellow, or “Use with Increased Caution and with More Frequent Monitoring” in red. The GeneSight report also alerts healthcare providers to the implications of the patient’s genetic information to a drug’s dosage, and FDA-approved package insert information.
Altar’s co-authors on the paper, “ Clinical validity: Combinatorial pharmacogenomics predicts antidepressant responses and healthcare utilizations better than single gene phenotypes,” include Daniel Hall-Flavin, M.D., Associate Professor of Psychiatry at the Mayo Clinic, and Joseph Carhart, M.A., Josiah D. Allen, Bryan M. Dechairo, Ph.D. and Joel G. Winner, M.D., of Assurex Health. Assurex Health funded the paper.