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Genetic mutation damages DNA and alters RNA splicing in familial amyotrophic lateral sclerosis

(FALS) is a that has been linked to mutations in several different genes, including the gene encoding the DNA/ binding protein .

It is unclear how FUS mutations promote FALS-associated symptoms.

In the issue of the , Eric Huang and colleagues of the developed a transgenic mouse model of FUS-associated FALS. FUS-R521C mice exhibited phenotypes similar to patients, such as neurological dysfunction and pronounced DNA damage.

The authors identified brain-derived neurotrophic factor (Bdnf) as a target of mutant FUS.

Treatment of FUS-R521C neurons with BNDF only partially restored dendrite function.

Evaluation of spinal cords from FUS-R521C revealed that there were multiple defects in the transcription and splicing of genes associated with dendrite growth and function.

TITLE: ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects

Source

Journal of Clinical Investigation