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Genome-wide association study of cannabis dependence

Cannabis dependence is a serious problem worldwide and it is of growing importance in the United States as marijuana becomes increasingly legal.

A new study published online by JAMA Psychiatry examined what specific genetic variants might contribute to cannabis dependence.

Joel Gelernter, M.D., of the Yale School of Medicine, New Haven, Conn., and coauthors conducted a genome-wide association study for DSM-IV cannabis dependence criterion in three independent substance dependence study groups among African American and European American participants.

The authors report cannabis dependence has a genetic risk component that may overlap with other psychiatric disorders.

Study: Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks, Richard Sherva PhD, Qian Wang MS, Henry Kranzler MD, Hongyu Zhao PhD, Ryan Koesterer MS, Aryeh Herman PsyD, Lindsay A. Farrer PhD, Joel Gelernter MD, JAMA Psychiatry, doi:10.1001/jamapsychiatry.2016.0036, published online 30 March 2016.

The article contains conflict of interest and funding/support disclosures. Please see the article for additional information, including author contributions and affiliations, financial disclosures, funding and support, etc.

Editorial: Genome-wide Significant Associations for Cannabis Dependence Severity, James T. R. Walters MRCPsych, PhD, Michael J. Owen FRCPsych, PhD, JAMA Psychiatry, doi:10.1001/jamapsychiatry.2016.0046, published online 30 March 2016.