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Gestational diabetes and the therapeutic potential of umbilical cord-derived stem cells

Multipotent cells isolated from the human umbilical cord, called mesenchymal (hUC-MSCs) have shown promise for use in cell therapy to treat a variety of human diseases. However, intriguing new evidence shows that hUC-MSCs isolated from women with demonstrate premature aging, poorer cell growth, and altered metabolic function, as reported in an article in and Development, a peer-reviewed journal from , , publishers. The article is available free on the website until February 17th, 2015.

Jooyeon Kim and coauthors from University of Ulsan College of Medicine, Kyung Hee University College of Medicine, and Seoul National University Bundang Hospital, Seoul, Korea, compared the growth and viability characteristics of hUC-MSCs from the umbilical cords of pregnant women with and without gestational diabetes. They evaluated cell growth, cellular senescence, mitochondrial function-related gene expression as a measure of metabolic activity, and the stem cells’ ability to differentiate into various cell types such as bone and fat cells. They report their findings in the article “Umbilical Cord Mesenchymal Stromal Cells Affected by Gestational Diabetes Mellitus Display Premature Aging and Mitochondrial Dysfunction.”

“We are only just beginning to scratch the surface of understanding how environmental and gestational stressors of all kinds affect stem cell populations,” says Editor-in-Chief Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI. “The work described offers a non-invasive assay to help determine risk of developmental clinical vulnerability.”

Source

Umbilical Cord Mesenchymal Stromal Cells Affected by Gestational Diabetes Mellitus Display Premature Aging and Mitochondrial Dysfunction

Kim Jooyeon, Piao Ying, Kim Pak Youngmi, Chung Dalhee, Han Yu Mi, Hong Joon Seok, Jun Eun Jeong, Shim Jae-Yoon, Choi Jene, and Kim Chong Jai. Stem Cells and Development. doi:10.1089/scd.2014.0349.

Mary Ann Liebert, Inc./Genetic Engineering News