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GI problems in autism may originate in genes, study suggests

Researchers at Columbia University Medical Center (CUMC) have found evidence in mice that, for some types of autism, gastrointestinal difficulties may originate from the same genetic changes that lead to the behavioral and social characteristics of the condition. The study was published in the Journal of Clinical Investigation.

GI Motility
Maps of colon contractions in wild type mice (left) compared to the autism model mice (right). Intestinal motility in the model mice was abnormally slow.
Credit: Kara Gross Margolis, M.D., and Michael Gershon, M.D., Columbia University Medical Center