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Gonadotropin-releasing hormone neurons influenced by Arg-Phe-amide-related peptides

During the last decade, our understanding of this hypothalamus-pituitary-gonadal axis has quickly expanded.

Two novel hypothalamic Arg-Phe-amide- related peptides, kisspeptin and gonadotropin-inhibitory hormone, may be important regulators of the reproductive axis. Kisspeptins are currently recognized as the most potent activators of the hypothalamus-pituitary-gonadal axis. Kisspeptin and its receptor, G protein-coupled receptor 54 (GPR54), are expressed on neurons, thus regulating the reproductive axis. Kisspeptins strongly release gonadotropin- releasing hormone and , even at pre-puberty. Kisspeptin/GPR54 is important for the regulation of sexual maturation and the development of the reproductive system.

Prof. Haluk Kelestimur and colleagues from , Firat University, Elazig, Turkey used the GT1-7 cell line-expressing gonadotropin-releasing hormone as a model and found that gonadotropin-inhibitory hormone and Arg-Phe-amide-related peptide-1 may have inhibitory effects on kisspeptin-activated gonadotropin-releasing hormone neurons without affecting [Ca2+]i.

These findings, which were in the journal Neural Regeneration Research (Vol. 8, No. 18, 2013) suggest that Arg-Phe-amide-related-peptide-1, in addition to Arg-Phe-amide-related-peptide-3, may be involved in the modulation of the hypothalamus- pituitary-gonadal axis.


Article: ” Arg-Phe-amide-related peptides influence gonadotropin-releasing hormone neurons,” by Haluk Kelestimur1, Emine Kacar1, Aysegul Uzun2, Mete Ozcan3, Selim Kutlu1 (1 Department of Physiology, Medical School, Firat University, Elazig, Turkey; 2 Department of Biochemistry, Medical School, Karadeniz Technical University, Elazig, Turkey; 3 Department of Biophysics, Medical School, Firat University, Elazig, Turkey)

Kelestimur H, Kacar E, Uzun A, Ozcan M, Kutlu S. Arg-Phe-amide-related peptides influence gonadotropin-releasing hormone neurons. Neural Regen Res. 2013;8(18):1714-1720. Neural Regeneration Research