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Groundbreaking Advancements Lead To Development Of New Cranial Neural Crest Cell Line

Researchers have successfully developed a of neural crest cells derived from mice that can be grown in large quantities in the laboratory and that demonstrates the potential to develop into many different needed throughout the body. This powerful new research tool for understanding stem and human development and disease is described in an article published in , a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Stem Cells and Development website.*

Mamoru Ishii and colleagues from University of Southern California, Los Angeles, and , Pasadena, CA, present their work leading to the development of two neural crest cell lines with stem cell characteristics in the article “A Stable Cranial Neural Crest Cell Line from Mouse.” The 09-1 cell line is capable of differentiating into four main cell types: bone, muscle, brain, and cartilage/connective tissue.

“This exciting report is the first to characterize cranial neural crest cell lines isolated from the mouse embryo, which definitively demonstrate multipotency and long-term propagation,” says , PhD, research professor, Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine.


* http://www.liebertpub.com/scd
Mary Ann Liebert, Inc./Genetic Engineering News