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Groundbreaking Advancements Lead To Development Of New Cranial Neural Crest Cell Line

Researchers have successfully developed a stable population of cells derived from mice that can be grown in large quantities in the laboratory and that demonstrates the potential to develop into many different cell types needed throughout the body. This powerful new research tool for understanding stem cell biology and and disease is described in an article published in Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, , publishers. The article is available free on the Stem Cells and Development website.*

Mamoru Ishii and colleagues from , Los Angeles, and , Pasadena, CA, present their work leading to the development of two lines with stem cell characteristics in the article “A Stable Cranial Line from Mouse.” The 09-1 cell line is capable of differentiating into four main cell types: bone, muscle, brain, and cartilage/connective tissue.

“This exciting report is the first to characterize cranial neural crest cell lines isolated from the mouse embryo, which definitively demonstrate multipotency and long-term propagation,” says Editor-in-Chief Graham C. Parker, PhD, research professor, Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine.


* http://www.liebertpub.com/scd
Mary Ann Liebert, Inc./Genetic Engineering News