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HDAC3 In Stem Cell Functions Essential For Blood Cell Development

The expression of specific genes is partially dictated by the way the DNA is packed into chromatin, a tightly packed combination of DNA and proteins known as histones.

HDAC3 is a chromatin-modifying enzyme that regulates , , and genome instability and it has previously been shown to associate with the oncoproteins that drive leukemia and lymphoma.

In this issue of the , and colleagues at examined the role of HDAC3 in the development of (hematopoiesis) by disrupting its expression in mice. Loss of Hdac3 nearly eliminated all blood immune cells and caused mild anemia. Hiebert and colleagues observed that, in the absence of Hdac3, stem and progenitor cells, which give rise to , failed to grow normally.

These studies identify a role for HDAC3 in stem cell functions and possibly bone marrow failure syndromes, in which the bone marrow fails to produce blood cells.

TITLE: HDAC3 is essential for DNA replication in hematopoietic progenitor cells



Journal of Clinical Investigation