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Healthy People Harmed By Platelet Activation Caused By Passive Smoking

“It is well known that passive is harmful for cardiovascular health, but the mechanism has not yet been discovered,” said Dr Kaya. “We investigated the effects of passive on the levels of three parameters – mean platelet volume (MPV), carboxyhemoglobin (COHb) and lactate – in an effort to further understand this mechanism. We also looked at the correlation between the three parameters.”

Mean platelet volume (MPV) is a well established indicator of platelet activation that is increased in acute thrombotic events. It is suspected that carbon monoxide (CO) plays a major role in -induced cardiovascular diseases. When CO binds with hemoglobin (Hb) in it is called COHb. Lactate accumulates in the blood when the supply of oxygen to is limited.

For the study, 55 healthy nonsmoker volunteers (males 30%; mean age 26±5 years) were prospectively enrolled. Blood samples for measurements of MPV, COHb and lactate were taken at baseline and after spending one an hour in a .

The blood levels of all three parameters were statistically higher after subjects were exposed to (see figure 1). COHb increased from 0.8±0.3% at baseline to 1.2±0.4% after one hour in a smoking room (p=0.001). Lactate increased from 0.70±0.2mmol/L to 2.2±0.9mmol/L (p=0.001). MPV increased from 7.8±0.4 femtolitres (fL) to 8.5±0.6fL (p= 0.001). Dr Kaya said: “These results show that increases platelet activation and increases CO and lactate levels in the blood.”

The researchers found significant correlations between MPV and COHb levels (r= 0.55, p=0.0001) and between MPV and lactate levels (r= 0.65, p=0.0001) after smoking. There was also a remarkable relation between COHb and lactate levels after smoking (r= 0.78, p=0.0001). Dr Kaya said: “Previous studies have suggested that the chemicals in cigarette smoke, especially nicotine and CO, increase platelet-activating factor. The correlations found in our study suggest that the CO in cigarette smoke also increases MPV levels. It is likely that lactate levels increased because oxygen levels in the blood dropped as CO increased.”

He concluded: “We have shown that 1 hour exposure to passive smoking increases platelet activation, which could be the mechanism by which it contributes to increased risk of thrombotic events in healthy people. It is likely that prolonged exposure to passive smoking could have even greater effects. Healthy people should avoid exposure to passive smoking so that they do not increase their risk of thrombotic events.”

Source

The authors received no financial support for the research, authorship, and/or publication of this article.
European Society of Cardiology