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Heart muscle regeneration induced by long-term use of ventricular assist devices

Prolonged use of a (LVAD) by patients with heart failure may induce regeneration of heart muscle by preventing oxidative damage to a cell-regulator mechanism, investigators have found.

Hesham Sadek, UT Southwestern Medical Center
Dr. , left, Dr. , and Dr. examine two models of left ventricular assist devices.
Credit:UT Southwestern


This paper appears online in the Journal of the American College of Cardiology.

Other UT Southwestern investigators involved in this study are Dr. Diana Canseco, Assistant Instructor in Internal Medicine; Dr. Wataru Kimura, Assistant Instructor in Internal Medicine; Dr. Sonia Garg, cardiology fellow; Dr. Shibani Mukherjee, Instructor in Psychiatry; Dr. , research assistant; Salim Abdisalaam, graduate student; Dr. Sandeep Das, Associate Professor of Internal Medicine; and Dr. Asaithamby Aroumougame; Assistant Professor of Radiation Oncology.

Dr. Drazner holds the James M. Wooten Chair in Cardiology. Dr. Hill holds the Frank M. Ryburn, Jr. Chair in Heart Research and the James T. Willerson, M.D. Distinguished Chair in Cardiovascular Diseases. Dr. Olson holds the Annie and Willie Nelson Professorship in Stem Cell Research, the Pogue Distinguished Chair in Research on Cardiac Birth Defects, and the Robert A. Welch Distinguished Chair in Science.

This research is supported by grants from NIH and the Foundation for Heart Failure Research.

UT Southwestern Medical Center