HER2-Positive Breast Cancer Patients Prefer Faster Subcutaneous Administration Of Herceptin® (Trastuzumab) To IV
Further research also reveals quicker administration of Herceptin could save NHS £15m compared to current practice1
Results from the PrefHer (Patient Preference for Subcutaneous (SC) versus Intravenous (IV) Herceptin) trial show that 92% of early HER2-positive breast cancer patients favoured quicker SC administration of Herceptin compared to the standard IV infusion.1 Presented at the St. Gallen Breast Cancer Conference in Switzerland.
The primary reasons for preferring SC administration given by patients in the trial were less pain/discomfort and time saving.1 Herceptin SC was preferred by 92% of patients (95% CI 87-95%; p<0.0001), with 7% preferring IV administration (95% CI 4-11%) and 2% with no preference (95% CI 1-4%). Of the patients who preferred SC, overall preferences were ‘very strong’ in 74%, ‘fairly strong’ in 21% and ‘not very strong’ in 6%.1 AEs were reported in 69% of patients (63% grade 1, 34% grade 2, 6% grade 3, no grade 4/5, 3% SAEs) with no new safety signals.1
Professor Lesley Fallowfield, Director Sussex Health Outcomes Research & Education in Cancer, University of Sussex said: “Time is precious to women with breast cancer, far too precious to be waiting around in busy chemotherapy centres. If subcutaneous delivery of Herceptin were to replace intravenous administration in the NHS then patients would spend less time in hospital and more time getting on with their lives. The results of this important study examining patient preferences are unequivocal. Women found subcutaneous delivery swifter, more comfortable and more convenient than IV. If this method is adopted in the NHS then the quality of life of women with HER 2-positive breast cancer could be dramatically improved.”
Further research, also presented at the St. Gallen Breast Cancer Conference, estimated that the NHS could save £15m by administering Herceptin subcutaneously to early and metastatic breast cancer patients versus the standard IV infusion.2 The study, produced and developed by Roche Products Ltd, shows the main source of cost saving would come from a reduction in healthcare professional time associated with preparation and administration of SC versus IV Herceptin.
The study concluded that any savings generated could be reinvested in order to improve overall patient care and that reductions in patient time in hospital could potentially result in a better patient experience and improved hospital efficiency.2
Currently, not all of the cancer treatments deemed to be clinically effective are routinely available on the NHS. It’s estimated that the average cost of purchasing, administering and managing a cancer treatment which is not routinely funded by the NHS is £20,821.3 This means a saving of £15millon could provide essential cancer treatment to an additional 720 patients.2,3
In addition, the rate of cancer cases is expected to rise by 45% between 2007 and 20304 and the growing patient demand will contribute to mounting pressure on staff capacity in chemotherapy suites. The government is committed to maintaining the NHS budget in real terms, but historically NHS spending has risen by 4% a year as a result of population growth and inflation.5 Essentially, with no additional budget, this means achieving 4% efficiency savings year by year or, in cash terms, saving £15-20 billion between 2011 and 2015.6 Solutions, such a switching to subcutaneous administration, could ease some of this burden and contribute to a better patient experience.2
About HER2-positive breast cancer
HER2 is a receptor found on the surface of all cells. Like a satellite dish, it sends messages or ‘signals’ into the cell telling it to survive and multiply.7 In HER2-positive breast cancer, there are too many HER2 receptors on the surface of cancerous cells. As a result, the cells receive a high number of ‘survive and multiply’ signals – causing rapid growth and spread of the tumour.7
HER2-positive breast cancer accounts for up to 25% of all breast cancers,8 and is known to be a particularly aggressive form of the disease.9 It becomes ‘advanced’ or ‘metastatic’ when it has spread to other parts of the body, outside the breast where it was first diagnosed.
About Herceptin® (trastuzumab)
Herceptin is a humanised antibody designed to target and block the function of HER2, a protein produced by a specific gene with cancer-causing potential. The mode of action of Herceptin activates the body’s immune system and suppresses HER2 to target and destroy the tumour. Herceptin has demonstrated efficacy in treating both early and advanced (metastatic) HER2-positive breast cancer as well as HER2-positive advanced (metastatic) stomach cancer.10,11 Given on its own as monotherapy as well as in combination with or following standard chemotherapy, Herceptin has been shown to improve disease-free survival, overall survival and response rates while maintaining quality of life in people with HER2-positive breast and stomach cancer. Like most treatments, Herceptin can be associated with side effects. The most common of these are mild flu-like symptoms such as chills and/or fever that usually occur as a reaction to its administration.11 Herceptin can also have effects on the heart that are treatable in the majority of cases.11 It was first licensed in Europe in 2000 for the treatment of HER2-positive metastatic breast cancer, and in 2006 for early breast cancer. Herceptin is marketed in the US by Genentech, in Japan by Chugai and internationally by Roche.
A summary of product characteristics is available on the EMA Website.
1. Pivot, X et al. Patient preference for subcutaneous versus intravenous trastuzumab: Results of the PrefHer study presented at St Gallen (March 2013)
2. Samanta, K et al. The study, Cost Savings with Herceptin subcutaneous vs intravenous administration: A time in motion study. Roche Products Ltd. Presented at St Gallen (March 2013)
3. Rarer Cancers Forum (2008), Exceptional England? An investigation of the role of Primary Care Trusts in making cancer medicines available through exceptional cases processes
4. Mistry, M. Cancer incidence in the United Kingdom: projections to the year 2030, British Journal of Cancer (2011) 105, 1795-1803
5. NHS Choices. About the NHS. Available here. Pages/overview.aspx Last accessed March 2013
6. Department of Health. NHS Operating Framework for the NHS in England 2011-2012.Available here (PDF) Last accessed March 2013
7. Macmillan – Cancer Information – Hormone and HER2 receptors Last accessed February 2013
8. Macmillan – About Breast Cancer Last Accessed February 2013
9. Boekhout, A.H. et al. (2011) Clinical Pharmacology: Concise Drug Reviews. Trastuzumab. The Oncologist; 16: 800-810
10. Rugo H et al. (2010) Effect of Trastuzumab on Health – Related Quality of Life in Patients With HER2-Positive Metastatic Breast Cancer: Data From Three Clinical Trials. Clin Breast Cancer 1;10(4):288-9
11. Herceptin® SmPC Roche Products Ltd. Herceptin® SmPC. January 2013 available here
Source: Roche in the UK