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How oxidative stress and mitochondrial damage relate to neurodegenerative diseases

Oxidative stress and mitochondrial damage have been implicated in the pathogenesis of several , including Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis.

Oxidative stress is characterized by the overproduction of reactive oxygen species, which can induce mutations, damage the , alter membrane permeability, and influence Ca2+ homeostasis and mitochondrial defense systems. All these changes are implicated in the development of these neurodegenerative diseases, mediating or amplifying neuronal dysfunction and triggering neurodegeneration.

A recent article published in the (Vol. 8, No. 21, 2013), entitled “Oxidative stress, mitochondrial damage and neurodegenerative diseases”, summarizes the contribution of oxidative stress and mitochondrial damage to the onset of neurodegenerative diseases and discusses strategies to modify mitochondrial dysfunction that may be attractive therapeutic interventions for the treatment of various neurodegenerative diseases.

Article: ” Oxidative stress, mitochondrial damage and neurodegenerative diseases ” by Guo CY, Sun L, Chen XP, Zhang DS. (Neural Regen Res. 2013;8(21):2003-2014.)


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