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Identification Of New Therapeutic Target For Prostate Cancer

A small, naturally occurring nucleic acid sequence, called a , known to regulate a number of different cancers, appears to alter the activity of the , which plays a critical role in prostate . Directly targeting microRNA-125b to block androgen receptor activity represents a novel approach for treating castrate-resistant prostate . This promising new strategy for improving the effectiveness of anti-androgenic and other is described in an article in BioResearch Open Access, a new bimonthly peer-reviewed open access journal from , Inc.. The article is available free online at the BioResearch Open Access website.*

is the most common non-skin cancer affecting men and the second most common cause of cancer death among men. In the article “miR-125b Regulation of Androgen Receptor Signaling Via Modulation of the Receptor Complex Co-Repressor NCOR2,” Xiaoping Yang, Lynne Bernis, Lih-Jen Su, Dexiang Gao, and Thomas Flaig, University of Colorado Denver (Aurora) and University of Minnesota (Duluth), looked for targets of microRNA-125b that might shed light on its role in regulating and found that it directly inhibits NCOR2, which acts to repress the androgen receptor. The authors point out that “the androgen receptor is a critical therapeutic target in ” and that alterations in the receptor are essential for the development of castrate-resistant , in which the disease no longer responds to hormonal therapies.

“This research provides new insight into the mechanism of miR-125b regulation of castrate-resistance prostate cancer through the identification of a novel target for miR-125b,” says Editor-in-Chief Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland. “The clinical implications of this study are that targeted regulation of this miRNA may lead to more effective anticancer therapies.”

Source

*http://www.liebertpub.com/biores
Mary Ann Liebert, Inc./Genetic Engineering News