To see right through something is to know its true intent – the same could be said to apply to biological tissues, especially tumors.
Bioluminescence imaging with a firefly enzyme, called luciferase, and its substrate D-luciferin, is widely used to monitor biological processes. However, the emission wavelength of bioluminescence produced by D-luciferin limits the sensitivity of this technique. At 562 nm, this light does not effectively penetrate biological tissues.
A luciferin analog generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging
Image Credit: Tokyo Institute of Technology