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Improved brain mapping tool 20 times more powerful than previous version

Salk Institute scientists have developed a new reagent to map the brain’s complex network of connections that is 20 times more efficient than their previous version. This tool improves upon a technique called rabies virus tracing, which was originally developed in the Callaway lab at Salk and is commonly used to map neural connections.

Improved Brain Mapping Tool 20 Times More Powerful than Previous Version
A Salk team builds upon their rabies virus technology to better map neurons across large swaths of the nervous system. In a mouse brain section (thalamus), neurons providing monosynaptic inputs to cortical inhibitory neurons are traced via rabies (blue). Purple counterstaining shows surrounding cellular architecture.
Credit: Salk Institute