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In A Mouse Model Of Polycystic Kidney Disease, Vitamin B3 Blocks Cyst Formation

(ADPKD) is an inherited systemic disorder caused by mutations in PKD1 or PKD2 that predominately affects the and is characterized by the formation of cysts in the and other organs.

Xiaogang Li and colleagues at the University of Kansas Medical Centr used a mouse model of ADPKD to explore the role of the protein sirtuin 1 in . They found that inhibition of sirtuin 1 activity using can reduced cyst formation in the kidneys of ADPKD mice. These findings suggest that therapeutics targeting sirtuin 1 could potentially be used to treat ADPKD.

TITLE: Sirtuin 1 inhibition delays cyst formation in autosomal dominant



Journal of Clinical Investigation