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In Atrial Fibrillation Patients On Rivaroxaban, More GI Bleeding Seen Than With Warfarin

Patients with (AF) experienced more major and non-major clinically relevant when taking than patients taking warfarin.

As part of the ROCKET AF trial, researchers from multiple institutions, including ; Mount Sinai Medical Center; Janssen Research & Development; and , randomized 14,264 patients with nonvalvular AF to receive either rivaroxaban or dose-adjusted warfarin. Post-hoc analysis was performed on all patients while receiving study medication until 2 days after the last dose.

Results showed that GI bleeding events (upper, lower, rectal) occurred more frequently in patients receiving rivaroxaban (n=394) than warfarin (n=290). In addition, major and nonmajor, clinically relevant bleeding occurred more frequently with rivaroxaban use than warfarin use. However, there were fewer fatal GI bleeds with rivaroxaban and the absolute fatality rate was very low.

Source

This study was presented during CHEST 2012, the annual meeting of the , held October 20 – 25, in Atlanta, Georgia.
American College of Chest Physicians