White adipose tissue stores excess calories as fat that can be released for use in other organs during fasting. Mammals also have small amounts of brown adipose tissue, which primarily acts as an effective fat burner for the production of heat. Now researchers from the University of Southern Denmark have uncovered the mechanism by which white fat cells from humans gets reprogrammed to become browner.
This image shows a human fat cell from Mandrup Group.
Credit: University of Southern Denmark
“Browning of human adipocytes requires KLF11 and reprogramming of PPAR super-enhancers”, “Genes and Development” , 1 January 2015; Vol. 29, No. 1
Authors: Anne Loft1, Isabel Forss1*, Majken Storm Siersbæk1*, Søren Fisker Schmidt1, Ann-Sofie Bøgh Larsen1, Jesper Grud Skat Madsen1,5, Didier Pisani4, Ronni Nielsen1, Mads Malik Aagaard1, Angela Mathison2, Matt J. Neville3, Raul Urrutia2, Fredrik Karpe3, Ez-Zoubir Amri4, Susanne Mandrup1#
* These authors contributed equally
1 Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark
2 Laboratory of Epigenetics and Chromatin Dynamics, Mayo Clinic, Rochester, MN 55905, USA
3 National Institute for Health Research, Oxford Biomedical Research Centre, Oxford, UK
4 Univ. Nice Sophia Antipolis, iBV, CNRS UMR 7277, INSERM U1091, 06100 Nice, France
5 NNF Center for Basic Metabolic Research, University of Copenhagen, DK-2200 Copenhagen, Denmark