Newly formed B cells take the easy way out when it comes to exiting the bone marrow, according to a study published in The Journal of Experimental Medicine.
B cell migration, tracked in these bone marrow images, was largely blocked after VCAM-1 was inhibited (right).
Image credit: Beck et al., 2014
CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow Beck, T.C., et al. 2014. J. Exp. Med. doi:10.1084/jem.20140457