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Inflammation Links Social Adversity And Diabetes

Diabetes is strongly associated with (SES): low income, low education, and low occupational status are all linked to a higher risk for diabetes. Trying to understand the mechanisms underlying the association, Silvia Stringhini from the Institute for Social and Preventive Medicine in Lausanne, Switzerland and colleagues report in this week’s that a substantial part of it appears to be attributable to .

“Taking together the evidence linking socioeconomic adversity to and to ” the authors write, “it seems reasonable to postulate that chronically increased inflammatory activity in individuals exposed to socioeconomic adversity over the entire lifecourse may, at least partially, mediate the association between socioeconomic status over the lifecourse and future risk.”

To test their hypothesis, they analyzed data from the Whitehall II study. Following the famous original Whitehall study that pioneered the study of social determinants of health, Whitehall II has followed over 10,000 participants, all British civil servants working in London, since the mid 1980s. The study is ongoing, and participants undergo regular health check-ups and also provide extensive information about their social situation every few years.

For their study, the researchers focused on 6387 participants who had provided information on their education level and current occupation (reflective of early adulthood and present socio-economic status, respectively) as well as their father’s occupation (a proxy for childhood socio-economic status). In addition, it was known which of the participants had developed diabetes and when, and whether and when their blood work had shown signs of chronic inflammation.

They found that cumulative exposure to low SES over the lifecourse and a downward trajectory from high SES in childhood to low SES in adulthood were associated with an increased risk of developing type 2 diabetes over the study period. In addition, inflammatory processes, measured repeatedly through biomarkers in the blood, explained as much as one third of this association.

“Assuming that our findings reflect a causal association”, the authors say, “our results suggest that tackling socioeconomic differences in inflammation, especially among the most disadvantaged groups, might reduce social inequalities in type 2 diabetes.”

They suggest that future studies should test interventions that reduce chronic inflammation, as “(such studies) will be necessary to determine the extent to which social inequalities attributable to chronic inflammation are reversible.”


Stringhini S, Batty GD, Bovet P, Shipley MJ, Marmot MG, et al. (2013) Association of Lifecourse Socioeconomic Status with Chronic Inflammation and Type 2 Diabetes Risk: The Whitehall II Prospective Cohort Study. PLoS Med 10(7): e1001479. doi:10.1371/journal.pmed.1001479

Funding: SS is supported by a post-doctoral fellowship awarded by the Swiss School of Public Health (SSPH+). MK is supported by the Medical Research Council (K013351), UK, the US National Institutes of Health (R01HL036310; R01AG034454), the EU New OSH ERA Research Programme and an ESRC professorship. MS is supported by the British Heart Foundation. MK is partially supported by MRC, Economic and Social Research Council Grant RES 596-28-0001 and National Heart Lung and Blood Institute Grant HL36310. DB was a Wellcome Trust fellow during the preparation of this manuscript. The Whitehall II study has been supported by grants from the British Medical Research Council (MRC); the British Heart Foundation; the British Health and Safety Executive; the British Department of Health; the National Heart, Lung, and Blood Institute (R01HL036310); the National Institute on Aging, NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: The authors have declared that no competing interests exist.

PLOS Medicine