3 days popular7 days popular1 month popular3 months popular

Intestinal Wound Repair Relies On ANXA1

The cells that line the intestine, known as the epithelium, can become injured in disease states such as . To repair the injury, cells must migrate to the wound; however, the signals that drive this migration are unknown.

In this issue of the , researchers led by Asma and Andrew Neish at Emory University identified signaling pathways that mediate the repair of the intestinal epithelium.

Using isolated epithelial cells and a mouse model of intestinal injury, Nusrat, Neish, and colleagues found that the protein ANXA1 promoted to mediate wound healing in the intestinal epithelium.

Additionally, they found greater levels of this protein in patients with ulcerative colitis. These findings suggest that ANXA1 could potentially be used as a therapeutic agent to promote healing of the intestines in patients with ulcerative colitis.

Asma Nusrat
Emory University, Atlanta, GA, USA


Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair

Journal of Clinical Investigation Dec. 17, 2012