Study of how gut bacteria team up to prevent C. difficile infection in mice could aid development of probiotics and diagnostic tools for humans
A Clostridium difficile cell, which the gut microbiome can team up to fend off — or not — depending on the makeup of the gut microbiome “village”.
Credit: Centers for Disease Control and Prevention
In addition to Schloss, the authors of the new paper are Alyxandria M. Schubert, Ph.D., a recent doctoral graduate, and Hamide Sinani.
The research was supported by the National Institutes of Health (GM099514, HG005975, AI090871 and DK034933)
Reference: Antibiotic-Induced Alterations of the Murine Gut Microbiota and Subsequent Effects on Colonization Resistance against Clostridium difficile mBIO, doi: 10.1128/mBio.00974-15, 14 July 2015 mBio vol. 6 no. 4 e00974-15 doi: 10.1128/mBio.00974-15