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Leaky channels could contribute to unusual heart arrhythmias

Leaks are not just problems for plumbers and politicians; researchers in Canada reveal how leaky could cause disruptions in . The study, published in , suggests that ion leaks in mutant sodium channels might contribute to an unusual set of .

Cardiac Na(v)1.5 Channel
This is an illustration of the cardiac Nav1.5 channel. The red circles indicate the locations of the R222Q and R225W mutations in the voltage-sensing region of domain 1 (DI).
Credit:Moreau et al., 2015


Gating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy Moreau, A., et al. 2015. J. Gen. Physiol. doi:10.1085/jgp.201411304

Rockefeller University Press