3 days popular7 days popular1 month popular3 months popular

Leaving A Bad Taste In Your Mouth – Sinusitis

The protects the from bacterial infections, but the cues that alert the to the presence of bacteria are not known.

In this issue of the , researchers led by Noam Cohen at the University of Pennsylvania demonstrated that the receptor T2R38 regulates the immune defense of the human upper airway.

Cohen and colleagues found that T2R38 was expressed in the cells that line the upper respiratory tract and could be activated by molecules secreted by Pseudomonas aeruginosa and other bacteria. Additionally, they found that common polymorphisms in the T2R38 gene were correlated with the incidence of bacterial .

These results demonstrate that genetic variation contributes to individual differences in susceptibility to respiratory infection. In a companion piece, Alice Prince of Columbia University discusses the role of bitter taste receptors in immune defense.

TITLE: T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection

http://www.jci.org/articles/view/64240?key=8713f7c1bd015e43f32d

ACCOMPANYING COMMENTARY TITLE: The bitter tast of infection

http://www.jci.org/articles/view/66182?key=3da926f3262c7c8e0664

Source

Journal of Clinical Investigation