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Leicester research team identifies potential new targets for cancer treatments

Research papers identify key steps in — and potential to inhibit cancer

Human Cancer Cells Going Through the Process of Division
These microscope images show human going through the process of division. The cell on the left is untreated whereas the cell on the right has lost Hsp70. This reveals how interfering with Hsp70 prevents assembly of the robust scaffold (green) on which chromosomes (blue) are separated. The red dots show where the scaffold attach to the chromosomes.


The two papers are:

L. O’Regan, J. Sampson, M.W. Richards, A. Knebel, D. Roth, F.E. Hood, A. Straube, S.J. Royle, R. Bayliss, and A.M. Fry (2015) Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression. Journal of Cell Biology. doi: 10.1083/jcb.201409151

S.L. Prosser, N.K. Sahota, L. Pelletier, C.G. Morrison, and A.M. Fry (2015) Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis. Journal of Cell Biology. doi: 10.1083/jcb.201412099

University of Leicester