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Liver Function Micromanaged By MiR-122

MicroRNAs (miRNAs) are endogenously encoded RNAs that regulate the stability or translation of , and emerging research suggests that they have diverse roles in normal physiology and disease.

In this issue, two groups investigated the role of the predominant liver miRNA, miR-122. and colleagues from in Taiwan, and a team led by , from Ohio State University generated mouse models of MiR-122 loss of function, and determined that the molecule was critically involved in modulating fat and cholesterol metabolism, and may also have a tumor suppressive function in hepatocytes.

In the accompanying commentary, and of the University of Pennsylvania discuss these findings, and suggest the possibility that miR-122 might be a promising therapeutic target in hepatocellular carcinoma.

TITLE: MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis

http://www.jci.org/articles/view/63455?key=23da2ddccba2899a53ce

ACCOMPANYING ARTICLE TITLE: Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver

http://www.jci.org/articles/view/63539?key=1d943d4c7b1a0ff69bdc

ACCOMPANYING COMMENTARY TITLE: miR-122 regulates hepatic lipid metabolism and tumor suppression

http://www.jci.org/articles/view/63966?key=0e4a7918b518d2fd2d0c

Source

Journal of Clinical Investigation