In recent years, researchers have hotly pursued immunotherapy, a promising form of treatment that relies on harnessing and training the body’s own immune system to better fight cancer and infection. Now, results of a study led by Johns Hopkins investigators suggests that a device composed of a magnetic column paired with custom-made magnetic nanoparticles may hold a key to bringing immunotherapy into widespread and successful clinical use. A summary of the research, conducted in mouse and human cells, appears online July 14 in the journal ACS Nano.
This is a graphic showing a process for producing large numbers of activated, customized T cells using magnetic nanoparticles and a column.
Credit: Credit: Karlo Perica/Johns Hopkins Medicine
Other authors on the study are Joan Glick Bieler, Christian Schutz, Jacqueline Douglass, Andrew Skora, Yen Ling Chiu, Mathias Oelke, Kenneth Kinzler, Shibin Zhou and Bert Vogelstein, all of The Johns Hopkins University.
This work was supported by the National Institute of Allergy and Infectious Diseases (grant numbers AI072677 and AI44129), the National Institute of General Medical Sciences (grant number GM 07309), the National Cancer Institute (grant numbers CA 43460, CA 62924, CA 09243 and CA108835), the Troper Wojcicki Foundation, the Virginia and D.K. Ludwig Fund for Cancer Research, the Sol Goldman Center for Pancreatic Cancer Research, the Commonwealth Foundation, and sponsored research agreements with Miltenyi Biotec and NexImmune.
Under a licensing agreement between NexImmune and the Johns Hopkins University, Jonathan Schneck and Mathias Oelke are entitled to a share of royalty received by the University on sales of products derived from this article. The terms of this arrangement are being managed by the Johns Hopkins University in accordance with its conflict of interest policies.