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Mainz researchers identify novel factor involved in autophagy

Insight may enable innovative approach for new concepts in the fight against neurodegenerative diseases

C. elegans
The transparent nematode C. elegans, only 1 millimeter in length, has characteristics which include a short life cycle and a fixed number of cells. It serves as a model organism primarily for research in developmental biology, genetics, and neurobiology.
Credit: Dr. , Medical Center


In addition to the Mainz-based team, biochemists from were also involved in the research project that stretched over several years. This received funding from a wide range of organizations, including the Alzheimer Forschung Initiative e.V., the (DFG) – also within the framework of the Collaborative Research Center 1080: “Molecular and cellular mechanisms of neural homoeostasis” -, the (ERC), and a number of foundations.


Spang N., Feldmann A., Huesmann H., Bekbulat F., Schmitt V., Hiebel C., Koziollek-Drechsler I., Clement A.M., Moosmann B., Jung J., Behrends C., Dikic I., Kern A., Behl C., RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy. 2014: 10(12):2297-309. DOI:10.4161/15548627.2014.994359

Johannes Gutenberg Universitaet Mainz