Connective tissues like cartilage are made of cross-linked bundles of collagen fibers. UC Davis biomedical engineers have discovered that reducing oxygen or adding an enzyme called LOX can make these bundles stronger. The technique can be used to strengthen both natural cartilage kept in the lab for transplant, and artificial cartilage grown in culture.
Credit: Eleftherios Makris and Kyriacos Athanasiou, UC Davis
Other authors on the paper are Donald Responte, Nikolaos Paschos and Jerry Hu, all at the Department of Biomedical Engineering. Funding was provided by the National Institutes of Health.
Tags: UC Davis, articular cartilage, connective tissues, tendons and ligaments, Eleftherios Makris, Kyriacos Athanasiou, Donald Responte