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Malaria-in-a-dish paves the way for better treatments

(MIT) researchers have engineered a way to use human , derived from induced , to screen potential and vaccines for their ability to treat the liver stage of . The approach may offer new opportunities for personalized testing and the development of more effective individually tailored drugs to combat the disease, which causes more than 500,000 deaths worldwide each year.

Malaria Infection in Stem Cell-Derived Liver Cells
Plasmodium vivax liver-stage infection in iPSC-derived liver cells at eight days after infection.
Credit:Ng et al.


Stem Cell Reports, Ng et al.: “Human Induced Pluripotent Stem Cell-Derived Hepatocyte-like Cells Support Plasmodium Liver Stage Infection In Vitro” DOI: 10.1016/j.stemcr.2015.01.002

Cell Press