The molecular intricacies of hunger and satiety, pivotal for understanding metabolic disorders and the problem of obesity, are not yet fully understood by scientists. However, new research from The Rockefeller University reveals an important new component of the system responsible for regulating food intake: a hormone called amylin, which acts in the brain to help control consumption.
Scientists found evidence of the metabolism-regulating protein amylin, shown in red, present in multiple regions throughout a brain area called the hypothalamus. Experiments suggest amylin produced by hypothalamic neurons helps reduce food consumption together with leptin.
Credit: Laboratory of Molecular Genetics at The Rockefeller University/Cell Metabolism