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Mice experience therapeutic changes in glioma after transplantation of neural stem cells

transplanted into tumor-bearing rats can hinder tumor cell growth and proliferation; however, the mechanism remains unclear.

Abnormal activation of the Ras/Raf/Mek/Erk signaling cascade plays an important role in .

Inhibition of this aberrant activity could effectively hinder glioma cell proliferation and promote .

To investigate the mechanism of glioblastoma treatment by trans-plantation with respect to the Ras/Raf/Mek/Erk pathway, Hua Li and team from the 476 Hospital of Chinese PLA observed Raf-1, Erk and Bcl-2 protein expression as well as Caspase-3 protein expression.

The researchers found that transplantation of neural stem cells could inhibit the abnormal activation of Ras/Raf/Mek/Erk signaling, thus promoting apoptosis and potentially treating glioma.

These findings are published in (Vol. 8, No. 19, 2013).

Article: ” Apoptosis in glioma-bearing rats after neural stem cell transplantation ” by Hua Li1, Zhenjun Chen1, Shaopeng Zhou2 (1 Department of Neurology, the 476 Hospital of Chinese PLA, Fuzhou 350002, Fujian Province, China; 2 Department of Anesthesiology, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Guangdong Province, China)

Li H, Chen ZJ, Zhou SP. Apoptosis in glioma-bearing rats after neural . Neural Regen Res. 2013;8(19):1793-1802. doi:10.3969/j.issn.1673-5374.2013.19.007

Source

Neural Regeneration Research