3 days popular7 days popular1 month popular3 months popular

MicroRNAs Regulate Insulin Production

Obesity and pregnancy are associated with , accompanied by an increase in the demand for insulin. To compensate the pancreas expands its population of insulin-producing cells.

Researchers led by at the have identified a microRNA that participates in beta islet expansion. In this issue of the , and colleagues report that decreases in the microRNA miR-338-3p were correlated with increases in the number of beta islets during pregnancy in rats.

Blocking miR-338-3p increased beta islet expansion, suggesting that regulation of this microRNA may be important in disease states associated with insulin resistance, such as gestational diabetes.

“MicroRNAs contribute to compensatory beta-cell expansion during pregnancy and obesity”
Romano Regazzi
University of Lausanne, Lausanne, CHE


Journal of Clinical Investigation Sept. 10, 2012