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Microsporidiosis a possible cause of infection in transplant patients

should be considered in febrile when common infections are not found or response to standard therapies is poor, according to an article being published in .

Microsporidiosis is an that can cause a spectrum of disease from mild diarrhea to disseminated, life-threatening infections. The disease is especially serious in immumosuppressed individuals, such as transplant recipients.

Researchers conducted an investigation into the cause of in three patients receiving solid organs from the same donor.

After treatment for suspected brucellosis and other common , the donor recipients remained ill. Kidney biopsy samples from one patient tested positive for infection with Encephalitozoon cuniculi, a microsporidial species recognized as a pathogen in humans. Serologic evidence of infection with this microsporidian was found in the donor and all three recipients had the same Encephalitozoon cuniculi genotype, confirming that the infection was transplant-transmitted.

Donor-derived disease should be considered when multiple recipients are ill.



Annals of Internal Medicine