Efflux pumps are surface proteins that prevent antimicrobial drugs from getting a foothold in a bacterial cell by identifying and pumping them out of the cell. New research suggests that small pieces of those drugs could keep the efflux pumps busy and allow the antimicrobial drugs to reach a critical mass inside the cell.
A small piece (lower left) of a larger drug molecule (top left) is enough to distract bacterial defenses and allow the larger molecule to remain inside the bacterium.
Credit: Image -Corey Compton/Brown University
ACS Infect. Dis., Just Accepted Manuscript DOI: 10.1021/id500009f Publication Date (Web): December 1, 2014