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Molecular decoys help overcome drug resistance

are surface proteins that prevent from getting a foothold in a by identifying and pumping them out of the cell. New research suggests that small pieces of those drugs could keep the efflux pumps busy and allow the antimicrobial drugs to reach a critical mass inside the cell.

[An effective decoy]
A small piece (lower left) of a larger (top left) is enough to distract bacterial defenses and allow the larger molecule to remain inside the bacterium.
Credit: Image -Corey Compton/Brown University


A Fragment-Based Strategy for Investigating and Suppressing the Efflux of Bioactive Compounds

ACS Infect. Dis., Just Accepted Manuscript DOI: 10.1021/id500009f Publication Date (Web): December 1, 2014

Brown University