Sometimes, a new way of looking at something can bring to light an entirely new perspective.
Using an MRI technique that is sensitive to certain byproducts of cell metabolism, including levels of glucose and acidity, University of Iowa researchers discovered previously unrecognized differences in the brains of patients with bipolar disorder. The T1rho MRI scans showed brain regions of elevated signal in the 15 participants with bipolar disorder compared to the 25 participants who did not have bipolar disorder. The primary regions of difference are the cerebral white matter (yellow) and the cerebellum (red).
Credit: University of Iowa
In addition to Wemmie and Johnson, the study team included UI researcher Jess Fiedorowicz, Vincent Magnotta, Robin Follmer, Ipek Oguz, Lois Warren, and Gary Christensen.
A major source of funding for the research was a philanthropic gift from UI alumnus Roger Koch, who established the Roger L. Koch Mental Illness Research Fund in 2010 through the University of Iowa Foundation.
The study was also supported by grants from the National Institutes of Health, the Department of Veterans Affairs, and NARSAD.