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Muscle Regeneration Promoted In Mouse Model Of Muscular Dystrophy

(DMD) is a degenerative caused by mutations in the protein dystrophin. Dystrophin functions to protect from injury and loss of functional dystrophin results in break down and loss of . A cellular signal relay system, known as a MAP kinase cascade, regulates the function of muscle stem cells, serving as a source of the new cells that are required for .

In this issue of the , researchers led by Anton Bennett at Yale University identified the protein MKP-5 as a negative regulator of MAP kinase cascades in muscle stem cells. Loss of MKP-5 in a mouse model of DMD enhanced the development of new muscle cells (myogenesis) and helped prevent muscle degeneration. These results identify MKP-5 as an important suppressor of myogenesis and suggest that therapeutics that inhibit MKP-5 could be useful in the treatment of degenerative muscle diseases.

TITLE: Improved regenerative myogenesis and in mice lacking MKP-5



Journal of Clinical Investigation