Rice-led study shows how particles quench damaging superoxides
A polyethylene glycol-hydrophilic carbon cluster developed at Rice University has the potential to quench the overexpression of damaging superoxides through the catalytic turnover of reactive oxygen species that can harm biological functions.
Credit:Errol Samuel/Rice University
Graduate student Errol Samuel and alumna Daniela Marcano, both of Rice, and Vladimir Berka, a senior research scientist at UTHealth, are lead authors of the study. Co-authors are Rice alumnus Austin Potter; alumnus Brittany Bitner and associate professor Robia Pautler of Baylor College of Medicine; instructor Gang Wu of UTHealth and Roderic Fabian of Baylor College of Medicine and the Michael E. DeBakey Veterans Affairs Medical Center.
Kent is a professor of neurology and director of stroke research and education at Baylor College of Medicine and chief of neurology and a member of the Center for Translational Research on Inflammatory Diseases at the DeBakey Center. Tour is the T.T. and W.F. Chao Chair in Chemistry as well as a professor of materials science and nanoengineering and of computer science and a member of Rice’s Richard E. Smalley Institute for Nanoscale Science and Technology. Tsai is a professor of hematology at UTHealth and adjunct professor of biochemistry and cell biology at Rice.
The Mission Connect Mild Traumatic Brain Injury Consortium from the Department of Defense and the National Institutes of Health, the Alliance for NanoHealth and UTHealth supported the research.
Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters. Doi: 10.1073/pnas.1417047112