On January 30, 2013 ACS Nano published a study by Ali Khademhosseini, PhD, MASc, a researcher in the division of biomedical engineering at Brigham and Women’s Hospital, detailing the creation of innovative cardiac patches that utilize nanotechnology to enhance the conductivity of materials to induce cardiac tissue formation. Creation of these ultra-thin cardiac patches put medicine a step closer to durable, high-functioning artificial tissues that could be used to repair damaged hearts and other organs.
The cardiac tissue patches utilize a hydrogel scaffolding reinforced by nanomaterials called carbon nanotubes. To create the patches, the researchers seeded neonatal rat heart muscle tissue onto carbon nanotube-infused hydrogels. These novel patches showed excellent mechanical integrity and advanced electrophysiological functions. Moreover, they demonstrated a protective effect against chemicals toxic to heart tissue.
Carbon-Nanotube-Embedded Hydrogel Sheets for Engineering Cardiac Constructs and Bioactuators, Su Ryon Shin, Sung Mi Jung , Momen Zalabany , Keekyoung Kim , Pinar Zorlutuna , Sang bok Kim , Mehdi Nikkhah, Masoud Khabiry , Mohamed Azize , Jing Kong , Kai-tak Wan , Tomas Palacios , Mehmet R Dokmeci , Hojae Bae , Xiaowu (Shirley) Tang , and Ali Khademhosseini, ACS Nano, Just Accepted Manuscript, DOI: 10.1021/nn305559j, Publication Date (Web): January 30, 2013