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Nerve injury and regeneration in critical illness polyneuropathy and myopathy

and are frequent complications of severe illness that involve sensorimotor axons and skeletal muscles, respectively.

Differentiating critical illness polyneuropathy from Guillain-Barré syndrome, especially the axonal variants, may be difficult on purely clinical grounds, as Guillain-Barré syndrome is known for its variable atypical manifestations.

Prof. Hongliang Zhang and team from the First Bethune Hospital, in China provide the latest knowledge concerning the pathophysiology of critical illness polyneuropathy/myopathy along with relevant clinical, diagnostic, differentiating, and treatment information for this debilitating neurological disease, and underscores the importance of differentiating critical illness polyneuropathy and myopathy from Guillain-Barré syndrome.

The relevant paper was published in Neural Regeneration Research (Vol. 9, No. 1, 2014).

Source

Article: “Critical illness polyneuropathy and myopathy: a systematic review ” by Chunkui Zhou1, 2, Limin Wu1, 3, Fengming Ni4, Wei Ji5, Jiang Wu1, Hongliang Zhang1 (1 Department of Neurology, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China; 2 Department of Neurology, the Second Part, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China; 3 Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, MA, USA; 4 Department of Radiotherapy, Oncology Center, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China; 5 Department of Vascular Surgery, People’s Hospital of Jilin Province, Changchun 130000, Jilin Province, China)

Zhou CK, Wu LM, Ni FM, Ji W, Wu J, Zhang HL. Critical illness polyneuropathy and myopathy: a systematic review. Neural Regen Res. 2014;9(1):101-110.

Neural Regeneration Research