Scars are prone to appear at high tension parts, such as the sternum, shoulder and back, which are serious clinical problems.
Surgeons reduce scar formation through Z, W, V-Y flap variation and reduced blade tension, but its specific mechanism is still not very clear.
Hu Xiao and colleagues from Shandong Provincial Hospital Affiliated to Shandong University verified that mechanical tension contributed to the formation of a hyperplastic scar in the back skin of rats, in conjunction with increases in both nerve density and nerve growth factor expression in the scar tissue.
These experimental findings indicate that the cutaneous nervous system plays a role in hypertrophic scar formation caused by mechanical tension, which have been published in Neural Regeneration Research (Vol. 8, No. 17, 2013).
Article: ” Mechanical tension promotes skin nerve regeneration by upregulating nerve growth factor expression,” by Hu Xiao, Dechang Wang, Ran Huo, Yibing Wang, Yongqiang Feng, Qiang Li (Department of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong Province, China)
Xiao H, Wang DC, Huo R, Wang YB, Feng YQ, Li Q. Mechanical tension promotes skin nerve regeneration by upregulating nerve growth factor expression. Neural Regen Res. 2013;8(17):1576-1581.