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Neural networks adapt to the presence of a toxic HIV protein

Nearly half of HIV infected patients suffer from impaired neurocognitive function. The HIV protein transactivator of transcription (Tat) is an important contributor to HIV neuropathogenesis because it is a potent neurotoxin that continues to be produced despite treatment with antiretroviral therapy.

Tat Alters the Excitability of Networked Neurons
Tat changes the activity of networked neurons and the network adapts to the presence of the toxin.
Credit: Dr. Stanley A Thayer, Dr. Kelly A. Krogh, Bentham Science Publishers