Increasing evidence has revealed that the activation of the JNK pathway participates in apoptosis of nerve cells and neurological function recovery after traumatic brain injury. However, which genes in the JNK family are activated and their role in traumatic brain injury remain unclear.
Dr. Jiang Long and colleagues from the First Affiliated Hospital of Kunming Medical University, China found that JNK3 expression was downregulated at early stages of brain injury, which may be associated with apoptosis of nerve cells.
Downregulation of JNK3 expression may promote the recovery of neurological function following traumatic brain injury.
These findings were published in the Neural Regeneration Research (Vol. 8, No. 16, 2013).
Article: ” JNK3 involvement in nerve cell apoptosis and neurofunctional recovery after traumatic brain injury,” by Jiang Long1, Li Cai1, Jintao Li2, Lei Zhang1, Haiyang Yang1, Tinghua Wang2 (1 Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China; 2 Neuroscience Institute of Kunming Medical University, Kunming 650500, Yunnan Province, China)
Long J, Cai L, Li JT, Zhang L, Yang HY, Wang TH. JNK3 involvement in nerve cell apoptosis and neurofunction recovery after traumatic brain injury. Neural Regen Res. 2013;8(16):1491-1499.