Cells provide individualized model for studying obesity and testing treatments
Columbia researchers have developed a method to generate hypothalamic-like neurons from human pluripotent stem cells. The hypothalamic cells, which are ordinarily inaccessible for direct investigation, will help the researchers study obesity.
Credit: Laboratory of Rudolph Leibe
The paper is titled, “Differentiation of hypothalamic-like neurons from human pluripotent stem cells.” Other key contributors of the study are: Liheng Wang (CUMC), Kana Meece (CUMC), Damian J. Williams (CUMC), Stephen H. Tsang (CUMC), and Sharon L. Wardlaw (CUMC). J Clin Invest. 2015;125(2):796–808. doi:10.1172/JCI79220
The authors declare no financial or other conflicts of interest.
The study was funded primarily by grants from the National Institutes of Health (RO1 DK52431-20), the New York Stem Cell Foundation, a NYSTEM IIRP award (C026184), the Foundation for Prader-Willi Research, the Rudin Foundation, the Russell Berrie Foundation Program in Cellular Therapy, and the Diabetes and Obesity Research Centers of Columbia University (P30 DK63608-12, P30 DK26687-33).