U. Iowa group creates insulin-producing cells that normalize blood-sugar levels in diabetic mice
University of Iowa researchers reprogrammed human skin cells to create induced pluripotent stem cells, which were then differentiated in a stepwise fashion to create insulin-producing cells. When these cells were transplanted into diabetic mice, the cells secreted insulin and reduced the blood sugar levels of the mice to normal or near-normal levels. The image shows the insulin-producing cells (right) and precursor cells (left).
Credit:University of Iowa
Human iPS Cell-Derived Insulin Producing Cells Form Vascularized Organoids under the Kidney Capsules of Diabetic Mice.Published: January 28, 2015 DOI: 10.1371/journal.pone.0116582
In addition to Zavazava, the UI research team included Sudhanshu Raikwar, Eun-Mi Kim, William Sivitz, Chantal Allamargot, and Daniel Thedens. The study was funded in part by grants from the National Heart Lung and Blood Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, both part of the National Institutes of Health, and the Department of Veterans Affairs.