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New cells may help treat diabetes

U. Iowa group creates insulin-producing cells that normalize blood-sugar levels in diabetic mice

Insulin-Producing Cells
researchers reprogrammed to create induced , which were then differentiated in a stepwise fashion to create insulin-producing cells. When these cells were transplanted into diabetic mice, the cells secreted insulin and reduced the of the mice to normal or near-normal levels. The image shows the insulin-producing cells (right) and (left).
Credit:University of Iowa


Human iPS Cell-Derived Insulin Producing Cells Form Vascularized Organoids under the Kidney Capsules of Diabetic Mice.Published: January 28, 2015 DOI: 10.1371/journal.pone.0116582

In addition to Zavazava, the UI research team included Sudhanshu Raikwar, Eun-Mi Kim, William Sivitz, Chantal Allamargot, and Daniel Thedens. The study was funded in part by grants from the National Heart Lung and Blood Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, both part of the National Institutes of Health, and the Department of Veterans Affairs.

University of Iowa Health Care