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New, faster therapeutic hypothermia techniques needed to optimize cardioprotection following a heart attack

Rapid lowering of body temperature following an (MI) can be an effective therapeutic strategy to minimize damage to the heart muscle caused by the loss and restoration of blood flow to the heart. While hypothermia shows clinical promise, current methods to cool the heart are insufficient. Faster, more effective techniques are needed to realize the full cardioprotective potential of this emerging intervention, as described in an article in and , a peer-reviewed journal from , , publishers. The article is available free on the Therapeutic Hypothermia and Temperature Management website until November 23, 2014.

In the article “Hypothermia in the Setting of Experimental Acute Myocardial Infarction: A Comprehensive Review,” Michael J. Herring and coauthors from Good Samaritan Hospital and Keck School of Medicine, University of Southern California (Los Angeles, CA) and Harbor-UCLA Medical Center (Torrance, CA) examine the benefits and limitations of past and current methods of delivering hypothermia. These include topical regional hypothermia, an open-chest method of cooling the heart; endovascular cooling using a heat exchange balloon catheter to cool the blood that flows through the heart; surface cooling with blankets or convective-immersion therapy; and other methods.

“This timely review on the use of therapeutic hypothermia targeting myocardial necrosis emphasizes the need for additional investigations to maximize the benefits of this experimental therapy in promoting recovery in this patient population,” says W. Dalton Dietrich, PhD, Editor-in-Chief of Therapeutic Hypothermia and Temperature Management and Kinetic Concepts Distinguished Chair in Neurosurgery, Professor of Neurological Surgery, Neurology and Cell Biology, University of Miami Leonard M. Miller School of Medicine.


Article adapted by Medical News Today from original press release.

Hypothermia in the Setting of Experimental Acute Myocardial Infarction: A Comprehensive Review, Herring Michael J., Hale Sharon L., Dai Wangde, Mesbah Oskui Peyman, and Kloner Robert A., Therapeutic Hypothermia and Temperature Management, doi:10.1089/ther.2014.0016, published online 1 October 2014.

Source: Mary Ann Liebert, Inc., Publishers