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New insight into inflammatory bowel disease may lead to better treatments

(IBD) afflicts 1.6 million people in the United States, causing abdominal pain, diarrhea, constipation, and other potentially debilitating symptoms.

Bacterial Particles Linked to Inflammatory Bowel Disease
Marked by yellow tags, the tiny particles released by this bacterium may help initiate inflammatory bowel disease, according to new research from in St. Louis.
Credit: Wandy Beatty


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The research was supported by the the and Kidney Diseases of the (), grant DK097079, and the National Institute of Child Health and Human Development, also of the , via the Pediatric Physician Scientist Program.

Hickey CA, Kuhn KA, Donermeyer DL, Porter NT, Jin C, Cameron EA, Jung H, Kaiko GE, Wegorzewska M, Malvin NP, Glowacki R, Hansson GC, Allen PM, Martens EC, Stappenbeck TS. Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles. Cell Host & Microbe, online May 13, 2015. DOI: 10.1016/j.chom.2015.04.002

Washington University School of Medicine