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New mechanism of inheritance could advance study of evolution, disease treatment

Results show that can last for 25+ generations

C. elegans Neurons and Germ Cells
UMD scientists have discovered a mechanism for transgenerational gene silencing in the roundworm Caenorhabditis elegans. Special help to visualize neurons (magenta) and germ cells (green) in the roundworm’s body.

Credit:Photo: Sindhuja Devanapally


This research was supported by the of the (Award Nos. R00GM085200 and R01GM111457). The content of this article does not necessarily reflect the views of this organization.

The research paper, “Double-stranded RNA made in C. elegans neurons can enter the germline and cause transgenerational gene silencing ,” Sindhuja Devanapally, Snusha Ravikumar and Antony M. Jose, was published online in the Feb. 2, 2015 early edition of the journal Proceedings of the National Academy of Sciences. Doi:10.1073/pnas.1423333112

University of Maryland