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New pathway for stalling BRCA tumor growth revealed

Findings could lead to new therapies for breast, ovarian, and other cancers

Picture of Fusing Chromosomes
Chromosomes (in blue) are fusing together at their telomere ends (pictured as red and green dots) when DNA repair has gone awry.
Credit:Courtesy of Nature and et al.


Funding support for the study was provided by the , the V-Foundation, the , a Pew Scholars Award, the , National Institutes of Health grant AG0386677, the Helen L. and Martin S. Kimmel Center for Stem Cell Biology, as well the University of Texas at Austin, and from the .

Besides Dr. Sfeir, other researchers involved in this study were lead investigator Pedro Mateos-Gomez, PhD, also at NYU Langone; Fade Gong, PhD, and Kyle Miller, PhD, at the University of Texas at Austin; and Eros Lazzerini-Denchi, PhD, at the Scripps Research Institute in La Jolla, Calif.

NYU Langone Medical Center / New York University School of Medicine