Findings could lead to new therapies for breast, ovarian, and other cancers
Chromosomes (in blue) are fusing together at their telomere ends (pictured as red and green dots) when DNA repair has gone awry.
Credit:Courtesy of Nature and Mateos-Gomez et al.
Funding support for the study was provided by the Breast Cancer Alliance, the V-Foundation, the U.S. Department of Defense Breast Cancer Research Program, a Pew Scholars Award, the Novartis Advanced Discovery Institute, National Institutes of Health grant AG0386677, the Helen L. and Martin S. Kimmel Center for Stem Cell Biology, as well the University of Texas at Austin, and from the Cancer Prevention Research Institute of Texas.
Besides Dr. Sfeir, other researchers involved in this study were lead investigator Pedro Mateos-Gomez, PhD, also at NYU Langone; Fade Gong, PhD, and Kyle Miller, PhD, at the University of Texas at Austin; and Eros Lazzerini-Denchi, PhD, at the Scripps Research Institute in La Jolla, Calif.